Coenzyme Q10: Mitigating Statin-Induced Mitochondrial Dysfunction

Can you take CoQ10 if you take a statin?

CoQ10 supplementation may also function as a natural aid in lowering cholesterol and improving heart health. While there aren’t enough studies to confirm how well it works to do this, it may be possible to combine CoQ10 with statins for better results.

Does CoQ10 help mitochondrial dysfunction?

CoEnzyme Q10 Typical dosing of CoQ10 is 5-15mg/kg of body weight, although “high dose” CoQ10 is common for patients with mitochondrial disease, as well as other mitochondrial-related disorders which are a result of secondary mitochondrial dysfunction (such as ALS).

Do statins deplete coenzyme Q10?

The statin medications routinely result in lower coenzyme Q10 levels in the serum. Some studies have also shown reduction of coenzyme Q10 in muscle tissue. Such coenzyme Q10 deficiency may be one mechanism for statin-induced myopathies.

Do statins cause mitochondrial dysfunction?

Muscle mitochondria plays a key role in aerobic fitness, which is the capacity for the body to use oxygen during exercise and a critical indicator of a person’s cardiovascular health. Research in animals had shown that some statins reduce the number of mitochondria in muscles and their ability to use oxygen.

Who cannot take CoQ10?

If you take medication for high blood pressure, talk to your provider before taking CoQ10, and DO NOT stop taking your regular medication. Blood-thinning medications: There have been reports that CoQ10 may make medications such as warfarin (Coumadin) or clopidigrel (Plavix) less effective at thinning the blood.

What supplements should I avoid when taking statins?

Certain herbal supplements, such as St. John’s wort and possibly quercetin, may decrease blood levels of some statin drugs, and when taken with atorvastatin, may actually result in increased cholesterol levels. Certain forms of magnesium may also decrease blood levels of statin drugs — particularly Crestor.

What is the best treatment for mitochondrial dysfunction?

Currently there is no highly effective treatment or cure for mitochondrial disorder. The management of mitochondrial disease is supportive therapy, which may include nutritional management, exercise and/or vitamin or amino acid supplements.

Can you reverse mitochondrial dysfunction?

Researchers have discovered that age-related mitochondrial dysfunction—which can ultimately lead to DNA damage and cell death—may be prevented and even reversed. The key lies in early and sustained interventions that support optimal mitochondrial health and function.

What do cardiologists say about CoQ10?

Coenzyme Q10, also known as CoQ10, is a substance that helps generate energy in your cells. Your body makes CoQ10 naturally, but its production tends to decrease with age. Many cardiologists recommend CoQ10 supplements, especially for patients with heart conditions.

What vitamin should not be taken with CoQ10?

High-dose vitamin D may also impair CoQ10 absorption in the gut. One study found 5000 IU vitamin D daily for 4 weeks decreased serum CoQ10 levels. More research is still needed on vitamin D and CoQ10 interactions. Until more evidence is available, avoid taking more than 1000-2000 IU vitamin D with CoQ10.

Does CoQ10 repair mitochondria?

Therefore, CoQ10 supplementation may ameliorate mitochondrial dysfunction and alleviate fatigue associated with PVFS through its ability to restore electron flow in the mitochondrial respiratory chain (MRC), which will enhance ATP generation by oxidative phosphorylation.

Should you take CoQ10 with a statin?

Statins decrease the body’s levels of coenzyme Q10 (CoQ10), and thus taking CoQ10 supplements (which are widely available over the counter in pharmacies) may help treat the muscle side effects from statins.

What drugs cause mitochondrial damage?

Drug classes such as statins, anti-diabetics, anti-epileptics, NSAIDs, anti-depressants, and certain antibiotics have been identified to induce mitochondrial toxicity (13, 18, 27), Table 1 summarizes how different drug classes affect mitochondrial function and insulin sensitivity.

What happens when you take CoQ10 every day?

Coenzyme Q10 (CoQ10) has links to improved aging, exercise performance, heart health, diabetes, fertility, and migraine. It may also counteract the adverse effects of statin medications. Typically, dosages of around 100 mg to 200 mg of CoQ10 per day are recommended, though some conditions may require higher amounts.

Is coenzyme Q10 bad for your liver?

Liver cells, called hepatocytes, are susceptible to oxidative stress. CoQ10 helps protect hepatocytes and the organelles inside them from threats like free radicals and lipid peroxidation, which in turn helps to preserve liver function.

When is CoQ10 contraindicated?

Medications for high blood pressure (Antihypertensive drugs) interacts with COENZYME Q10. Coenzyme Q10 seems to decrease blood pressure. Taking coenzyme Q10 along with medications for high blood pressure might cause your blood pressure to go too low.

At what age are statins no longer recommended?

Do not start a statin in patients ages ≥ 75 years who do not have known vascular disease or type 2 diabetes; start or continue a statin in all patients ages 75 to 84 with type 2 diabetes to prevent cardiovascular events and mortality; and start or continue a statin in patients ages > 75 years who have known vascular …

Does Omega 3 interfere with statins?

Some people may be able to take fish oil alongside statins. However, EPA and DHA have different effects on LDL. Some studies suggest that combining statins with DHA may increase LDL, which can be a problem for people who are taking statins to lower their LDL levels. EPA has no effect or a slight lowering effect on LDL.

How to reverse mitochondrial dysfunction?

By administering nutritional supplements with replacement molecules and antioxidants, oxidative membrane damage and reductions of cofactors in normal tissues can be reversed, protecting and restoring mitochondrial and other cellular functions and reducing chemotherapy adverse effects.

What triggers mitochondrial dysfunction?

What causes mitochondrial dysfunction? On a physiological level, mitochondrial dysfunction is caused by exposure to certain environmental factors (such as certain pharmaceutical drugs, occupational chemicals and cigarette smoke) or genetic abnormalities (of both mitochondrial and nuclear DNA).

What is the best supplement for mitochondria?

Resveratrol, omega-3 fatty acids, and CoQ10 are just some examples of supplements that can help mitochondria function at peak capacity and reduce the risk of mitochondrial dysfunction. Many other nutrients can benefit mitochondrial function, including: Alpha-lipoic acid (ALA) B vitamins.

Does CoQ10 help mitochondria?

Highlights. Coenzyme Q10 is essential for mitochondrial electron transport and support of proton pump and ATP production.

Are eggs good for mitochondria?

– Omega-3 fatty acids found in low-mercury wild-caught fish, grass-fed meat, nuts (especially walnuts), seeds, and egg yolks help build protective membranes around mitochondria, reducing cell damage and enhancing energy production.

What exercise is best for mitochondria?

In other words, the best exercises to increase mitochondria and their function is a well-rounded program of aerobic exercise, HIIT workouts, and strength training, which is exactly what leads to performance improvements on the bike.

What do cardiologists say about CoQ10?

Coenzyme Q10, also known as CoQ10, is a substance that helps generate energy in your cells. Your body makes CoQ10 naturally, but its production tends to decrease with age. Many cardiologists recommend CoQ10 supplements, especially for patients with heart conditions.

What are the symptoms of needing CoQ10?

Other neurological abnormalities that can occur in primary coenzyme Q10 deficiency include seizures, intellectual disability, poor muscle tone (hypotonia), involuntary muscle contractions (dystonia), progressive muscle stiffness (spasticity), abnormal eye movements (nystagmus), vision loss caused by degeneration ( …

What vitamin should not be taken with CoQ10?

High-dose vitamin D may also impair CoQ10 absorption in the gut. One study found 5000 IU vitamin D daily for 4 weeks decreased serum CoQ10 levels. More research is still needed on vitamin D and CoQ10 interactions. Until more evidence is available, avoid taking more than 1000-2000 IU vitamin D with CoQ10.

Should I take CoQ10 in the morning or at night?

The supplement may disrupt sleep for some people, so it’s best to take it in the morning or midday initially. Regardless of the timing, it’s recommended to take CoQ10 supplements with a meal that contains healthy fats, says Umo Callins, RDN, a dietitian with Well Rooted Health and Nutrition in Oklahoma City.

How do statins affect coenzyme Q10?

What is the role of coenzyme Q10 in mitochondrial respiration?

Do statins cause mitochondrial dysfunction?

Does CoQ10 supplementation improve mitochondrial function in statin users?